News

Celgene-backed cancer biotech Repare emerges from stealth with $68M

After 18 months being incubated by Versant Ventures, upstart Repare Therapeutics has emerged from stealth mode with an impressive $68 million, backing from Celgene and some big-name execs. The Montreal and Cambridge, Massachusetts, biotech saw founding investor Versant Ventures co-lead the series A round with MPM Capital. They were also joined by other syndicate investors … Continued

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Dr. David Lyden Receives Grants from the Sohn Conference Foundation

Researchers from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center have received two grants from the Sohn Conference Foundation to advance their investigation into how cancer spreads in children. Dr. David Lyden, the Stavros S. Niarchos Professor in Pediatric Cardiology and a professor of pediatrics, Dr. Haiying Zhang, an assistant professor of cell and … Continued

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The First Cell Inspired a Career of Genomic Discoveries & Cancer Research

Some people struggle to find their paths in life. Not Chris Mason, PhD, Associate Professor and geneticist at Weill Cornell Medicine in New York City. He had already determined he wanted to be a geneticist by the time he reached eighth grade. “I was—and still am—a curious kid. I wanted to know how the world … Continued

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Embryo Experiments Reveal Earliest Human Development, But Stir Ethical Debate

Ali Brivanlou slides open a glass door at the Rockefeller University in New York to show off his latest experiments probing the mysteries of the human embryo. “As you can see, all my lab is glass — just to make sure there is nothing that happens in some dark rooms that gives people some weird … Continued

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Cell scientist to watch – Christine Mayr

Abstract: Before completing a PhD in immunology at the Humbolt University of Berlin, Christine Mayr received a medical degree from the Freie Universität Berlin. She received postdoctoral training with Michael Hallek at the Ludwig Maximillian University in Munich.

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Tumor Exosome Protein Signatures Predict Future Organ Sites of Cancer Spread

Findings By Weill Cornell Medicine Explain Paget’s “Seed and Soil” Theory of Metastasis

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Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

Abstract: Cohesin complex members have recently been identified as putative tumor suppressors in hematologic and epithelial malignancies. The cohesin complex guides chromosome segregation; however, cohesin mutant leukemias do not show genomic instability.

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Loss of BAP1 function leads to EZH2-dependent transformation

Abstract: The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub).

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Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Abstract: Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression.

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A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

Abstract: Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on the analysis of protein-coding genes; however, most genetic abnormalities found in human cancer are located in intergenic regions.

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