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Why pancreatic ductal adenocarcinoma is so lethal

Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer, killing patients within a year. CSHL Professor Christopher Vakoc and his former postdoc Timothy Somerville discovered how pancreatic cells lose their identity, acquire a deadly new identity, and recruit nearby cells to help them grow, promote inflammation, and invade nearby tissues. This understanding could lead to new … Continued

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Microbe Mappers Are Tracking Covid-19’s Invisible Traces

DURING THE SECOND week of March, as the World Health Organization declared Covid-19 a global pandemic, a team of latex-gloved scientists from Cornell Weill Medical School fanned out across Penn Station armed with packs of sterile, long-armed swabs and a tripod-mounted instrument for capturing air samples. In New York City, the 100th person had just tested positive … Continued

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‘Spider-Man’ Immune Response May Promote Severe COVID-19

A menagerie of immune cells and proteins defend the human body, and a relatively obscure member of this crew is getting new attention as a possible target for treating COVID-19. Neutrophils make up more than half of our white blood cells and are often the first to arrive at the scene of infection. But historically … Continued

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What Does Cancer Metastasis Have to Do with Wound Healing? More than You Might Think

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How pancreatic RAS tumors protect themselves. Researchers point to a new protein — and maybe a new treatment

A couple years back, some cardiovascular specialists at Boston’s Brigham and Women’s Hospital stumbled across a surprising result. Novartis had tasked them with carrying out the long-range Phase III trial for canakinumab, an experimental anti-inflammatory drug the company was trying to market for cardiovascular disease. The main results were mixed — modest reductions in fatal … Continued

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Venture Capitalists Turn to Science in Search for Next Great Investment

THE PEW CHARITABLE TRUSTS / KARA COLEMAN (NOVEMBER 21, 2019) — Although Silicon Valley is often considered the birthplace of modern entrepreneurial leadership and ideas, scientists across the country are getting attention for groundbreaking work. Investment in health research and development grew 27 percent from 2013 to 2017, for example, and several members of the Pew biomedical … Continued

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Vicious circles: Ring-shaped DNA provides cancer cells with a malignant twist

Science Daily/University of California – San Diego (November 20, 2019) — Deoxyribonucleic acid or DNA encodes information, not only in its sequence but also in its shape. Building upon previous revelatory work, a team of scientists, led by researchers at University of California San Diego, the UC San Diego branch of the Ludwig Institute for … Continued

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Young Investigators Named Winners of 2019 Paul Marks Prize for Cancer Research

MEMORIAL SLOAN KETTERING CANCER CENTER (New York, NY), November 12, 2019 – Memorial Sloan Kettering (MSK) has named three investigators as the recipients of this year’s Paul Marks Prize for Cancer Research. The award recognizes promising scientists for their accomplishments in the area of cancer research. The winners for 2019 are Nathanael Gray, PhD, of the Dana-Farber … Continued

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Scientists Identify Protein that Promotes Brain Metastasis

WEILL CORNELL MEDICINE – A protein that breast, lung and other cancers use to promote their spread—or metastasis—to the brain, has been identified by a team led by Weill Cornell Medicine and New York-Presbyterian investigators. The protein, CEMIP, will now be a focus of efforts to predict, prevent and treat brain metastases, which are a … Continued

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Horwitz Prize Awarded for Work on Critical Cancer Pathway

COLUMBIA UNIVERSITY IRVING MEDICAL CENTER/EUREKALERT – Columbia University will award the 2019 Louisa Gross Horwitz Prize to three scientists: Lewis C. Cantley, Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center, New York, NY, USA, David M. Sabatini, Massachusetts Institute of Technology, Cambridge, Massachusetts, and Howard Hughes Medical Institute, Chevy Chase, MD, USA, and Peter K. … Continued

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