Professor of Pediatrics and Pathology
Institute for Cancer Genetics
Columbia University Medical Center
In our laboratory we analyze the genetics of human leukemia to decipher fundamental mechanisms that can be exploited for the development of new therapies.
Our Pershing Square Sohn Prize project will develop new approaches to analyze the dark matter of the leukemia genome and decipher the hidden code of regulatory elements that orchestrate the activity of leukemia cancer genes.
“Functional Dissection of Oncogenic Enhancers in T-cell Leukemia”
Following on the completion of the Human Genome Project and using innovative sequencing tools researchers are rapidly annotating the complete repertoire of genetic alterations in cancer. However most of these lesions are located in genomic “dark matter” outside well annotated genes.
“Getting the Pershing Square Sohn Prize it is not only an honor but also an exciting opportunity to address new questions and highly innovative questions in our research.”
In this research project we will develop innovative new tools to analyze the function of critical as yet un-annotated genomic sequences controlling the activity of MYC, a major cancer driving gene. These studies will shed light on the function and mechanisms of cancer-associated “dark matter” regions in the human genome opening new venues for the development of targeted therapies in human cancer.
“Innovation is a new, unforeseen, fundamental advance in knowledge and technology. Innovation is the engine of true transformative progress.”