CT Insider — New Haven, CT (February 21, 2023) A new gene editing technique developed by scientists from Yale University offers a powerful new tool to interrogate how genes work across a swath of biological disciplines, from cancer research to immunology. According to a study published in Nature Biotechnology, the technique called “CLASH” allows potentially thousands of genes to be tested at once, dramatically scaling up the speed of experimentation.
“It’s really simple nowadays to knock out or take a gene out, but it’s a lot harder to insert DNA,” said Sidi Chen, a 2021 PSSCRA winner and professor of genetics at Yale who developed the technology. “To scale up to high throughput is even harder, previously unthinkable.
Dr. Robert Sobol, the co-leader of the cancer biology program at Brown University, said, “It’s pretty impressive. This adds a whole new dimension to systems analysis in biology.”