COLUMBIA UNIVERSITY IRVING MEDICAL CENTER/EUREKALERT – Columbia University will award the 2019 Louisa Gross Horwitz Prize to three scientists:
1.) Lewis C. Cantley, Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center, New York, NY, USA,
2.) David M. Sabatini, Massachusetts Institute of Technology, Cambridge, Massachusetts, and Howard Hughes Medical Institute, Chevy Chase, MD, USA, and
3.) Peter K. Vogt, Scripps Research, La Jolla, CA, USA
for their seminal contributions to the role of the phosphoinositide 3-kinase (PI3K) pathway in physiology and oncogenesis.
Until the end of the 20th century, most cancer therapies worked by attacking replicating cells, an approach that devastated nearly as many normal cells as malignant ones. Discoveries of the processes that control the growth, division, and spread of cancer cells, and the signals that cause these cells to die naturally, gave rise to a new era of targeted therapies–drugs that focus on specific molecular targets associated only with cancer cells.