Researchers at the Stanford University School of Medicine and their collaborators at other institutions have identified a link between how proteins bind to our DNA and how cancer develops. This finding may allow researchers to predict cancer pathways and long-term patient outcomes. The research focuses on chromatin, the DNA-protein complex where all genes reside. Specifically, it evaluates chromatin’s … Continued
NEW YORK (GenomeWeb) – New evidence has emerged today showing that the inactivation or alteration of cancer suppressor genes can take place even if DNA itself remains unaltered. Reporting in Nature, investigators demonstrated that changes in mRNA due to a process called intronic polyadenylation (IPA) can drive development of some cancers by altering gene expression in … Continued
For the first time, Mount Sinai researchers have identified a way to make large numbers of immune cells that can help prevent cancer reoccurrence, according to a study published in August in Cell Reports. The researchers discovered a way to grow the immune cells, called dendritic cells, at large scale in the lab to study them … Continued
A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows. The discovery that the NOTCH1 pathway takes control of heat shock transcription factor 1 (HSF1) signaling in T cell acute lymphoblastic leukemia, or … Continued
TBR News Media They aren’t quite wonder twins, but some day the dedicated work of husband and wife scientists Christopher Vakoc and Camila dos Santos may help people batting against a range of cancers, from leukemia to breast cancer. Dos Santos and Vakoc are the first family of prize winners in the Pershing Square Foundation’s … Continued
Cold Spring Harbor, NY — Researchers have discovered a new kind of small-cell lung cancer (SCLC). The discovery paves the way for developing personalized medicine approaches to target this previously unnoticed form of the disease. “Cancer is not one thing, it’s actually hundreds of distinct diseases.” This common refrain helps explain the frustrating experience oncologists have … Continued
TBR News Media Up and coming scientists are often stuck in the same position as promising professionals in other fields. To get the funding for research they’d like to do, they need to show results, but to get results, they need funding. Joseph Heller, author of “Catch 22,” would certainly relate. A New York-based philanthropy … Continued
SEVEN NEW YORK CITY-AREA SCIENTISTS WIN PERSHING SQUARE SOHN PRIZE FOR YOUNG INVESTIGATORS IN CANCER RESEARCH The Pershing Square Sohn Research Alliance Has Invested $19 million in the Next Generation of New York City Medical Research Talent to Accelerate Breakthroughs in Cancer Research NEW YORK, May 22, 2018 – The Pershing Square Sohn Cancer Research … Continued
Cold Spring Harbor, NY – Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered that cells lacking the tumor-suppressor protein PTEN–a feature of many cancers– are particularly vulnerable to drugs that impair their energy-producing mitochondria. Such drugs induce them to literally eat themselves to death, the research shows. Unlike normal cells, cells without PTEN seem … Continued
–Versant-seeded company focused on applying novel biology to boost anti-tumor immunity– —Foundational science stems from landmark ER stress biology research at Weill Cornell Medicine— —Michael Aberman, M.D., former SVP of Strategy for Regeneron, appointed as President and Chief Executive Officer— NEW YORK–(BUSINESS WIRE)–Quentis Therapeutics Inc., a biotechnology company pursuing next-generation immuno-oncology research and drug development, … Continued