SciTech Daily –New York, NY (July 31, 2023) — New recent research from Yale has discovered a method to control the self-destructive tendencies of certain killer T cells utilized in cancer therapy. CAR T-cell (chimeric antigen receptor) therapy, a promising form of immunotherapy, involves reprogramming the patient’s T cells to enhance their ability to identify … Continued
The Rockefeller University – When we’re driving to a new destination, we often turn down the stereo as we follow the directions. What had been music suddenly sounds like noise, and it interferes with our focus. Our understanding of how infectious diseases like COVID affect human lungs has been similarly confounded by noise. Data from … Continued
Icahn School of Medicine at Mt. Sinai – Recent work with induced pluripotent stem cells has helped uncover complex mechanisms in myelodysplastic syndrome and acute myeloid leukemia for the first time. This discovery could pave the way for improving current treatments, or even for finding new ones. A decade ago, somatic mutations—those that occur after … Continued
CT Insider — New Haven, CT (February 21, 2023) A new gene editing technique developed by scientists from Yale University offers a powerful new tool to interrogate how genes work across a swath of biological disciplines, from cancer research to immunology. According to a study published in Nature Biotechnology, the technique called “CLASH” allows potentially thousands … Continued
Colorectal tumors are swarming with white blood cells, but whether these cells help or hinder the cancer is hotly debated. While some studies have shown that white blood cells heroically restrict tumor growth and combat colorectal cancer, equally compelling evidence casts the white blood cells as malignant co-conspirators—bolstering the tumor and helping it spread. Now, … Continued
Newswise — New York, NY (April 6, 2022)— Mutation of a gene called ARID2 plays a role in increasing the chance that melanoma, a deadly skin cancer, will turn dangerously metastatic, Mount Sinai researchers report. The findings suggest that patients whose melanoma tumors have an ARID2 mutation may have a more aggressive cancer and may need to be treated … Continued
A drug widely used in HIV therapy has shown to stop disease progression in 25 percent of patients with fourth-line metastatic colorectal cancer. Findings from the trial, published in Cancer Discovery, raise the possibility of an unexpected promising direction in cancer treatment, not just colorectal cancer. The drug used in the study was lamivudine, a reverse transcriptase inhibitor. … Continued
To understand cancer in humans, researchers at the Sloan Kettering Institute (SKI) are turning to our distant relatives from 425 million years ago: fish. A lot has evolved since then: Fish use their fins to swim, whereas we use our hands to play Wordle. But there remains a deep similarity, explains 2017 Pershing Square Sohn Prize winner Richard … Continued
Every year, thousands of biochemistry majors and medical students around the world learn to memorize the major biochemical pathways that allow cells to function. How these 10 or so pathways are described in textbooks hasn’t changed much since the early 20th century, when they were first discovered. But with the resurgence of interest in cancer metabolism in … Continued
An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe COVID-19 and other disorders that cause immune-mediated damage to the lungs, according to a preclinical study from researchers at Weill Cornell Medicine and Cold Spring Harbor Laboratory. The … Continued