Icahn School of Medicine at Mt. Sinai – Recent work with induced pluripotent stem cells has helped uncover complex mechanisms in myelodysplastic syndrome and acute myeloid leukemia for the first time. This discovery could pave the way for improving current treatments, or even for finding new ones. A decade ago, somatic mutations—those that occur after … Continued
CT Insider — New Haven, CT (February 21, 2023) A new gene editing technique developed by scientists from Yale University offers a powerful new tool to interrogate how genes work across a swath of biological disciplines, from cancer research to immunology. According to a study published in Nature Biotechnology, the technique called “CLASH” allows potentially thousands … Continued
The Pershing Square Sohn Cancer Research Alliance Is Now Accepting Applications for its 2023 Prize for Radically Innovative, Early-Career Cancer Researchers NEW YORK, OCTOBER 3, 2022 (Business Wire) – The Pershing Square Sohn Cancer Research Alliance (PSSCRA) today announced the opening of applications for the 2023 Pershing Square Sohn Prize for Young Investigators in Cancer … Continued
Colorectal tumors are swarming with white blood cells, but whether these cells help or hinder the cancer is hotly debated. While some studies have shown that white blood cells heroically restrict tumor growth and combat colorectal cancer, equally compelling evidence casts the white blood cells as malignant co-conspirators—bolstering the tumor and helping it spread. Now, … Continued
Newswise — New York, NY (April 6, 2022)— Mutation of a gene called ARID2 plays a role in increasing the chance that melanoma, a deadly skin cancer, will turn dangerously metastatic, Mount Sinai researchers report. The findings suggest that patients whose melanoma tumors have an ARID2 mutation may have a more aggressive cancer and may need to be treated … Continued
The Pershing Square Sohn Cancer Research Alliance Is Now Accepting Applications for its 2022 Prize for Early-Career, Radically Innovative Cancer Researchers NEW YORK, OCTOBER 4, 2021 (Business Wire) – The Pershing Square Sohn Cancer Research Alliance (PSSCRA) today announced the opening of applications for the 2022 Pershing Square Sohn Prize for Young Investigators in Cancer … Continued
Right now, in your body, lurk thousands of cells with DNA mistakes that could cause cancer. Yet only in rare instances do these DNA mistakes, called genetic mutations, lead to a full-blown cancer. Why? The standard explanation is that it takes a certain number of genetic “hits” to a cell’s DNA to push a cell … Continued
Messenger RNA (mRNA) vaccines may be the hottest thing in science now as they help turn the tide against COVID-19. But even before the pandemic began, Memorial Sloan Kettering researchers had already been working to use mRNA vaccine technology to treat cancer. Vinod Balachandran a physician-scientist affiliated with the David M. Rubenstein Center for Pancreatic Cancer Research and … Continued
Cancer cells can become resistant to treatments through adaptation, making them notoriously tricky to defeat and highly lethal. Cold Spring Harbor Laboratory (CSHL) Cancer Center Director and Pershing Square Sohn Cancer Research Alliance Scientific Review Council member David Tuveson and his team investigated the basis of “adaptive resistance” common to pancreatic cancer. They discovered one of the backups … Continued
Normal cells usually have multiple solutions for fixing problems. For example, when DNA becomes damaged, healthy white blood cells can use several different strategies to make repairs. But cancer cells may “put all their eggs in one basket,” getting rid of all backup plans and depending on just one pathway to mend their DNA. Cold … Continued