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SKI Scientists Discover a New Twist on an 80-Year-Old Biochemical Pathway

Every year, thousands of biochemistry majors and medical students around the world learn to memorize the major biochemical pathways that allow cells to function. How these 10 or so pathways are described in textbooks hasn’t changed much since the early 20th century, when they were first discovered. But with the resurgence of interest in cancer metabolism in … Continued

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PRESS RELEASE: The Pershing Square Sohn Cancer Research Alliance Is Now Accepting Applications for its 2022 Prize for Early-Career, Radically Innovative Cancer Researchers 

The Pershing Square Sohn Cancer Research Alliance Is Now Accepting Applications for its 2022 Prize for Early-Career, Radically Innovative Cancer Researchers  NEW YORK, OCTOBER 4, 2021 (Business Wire) – The Pershing Square Sohn Cancer Research Alliance (PSSCRA) today announced the opening of applications for the 2022 Pershing Square Sohn Prize for Young Investigators in Cancer … Continued

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Why Are Only Some Cells ‘Competent’ to Form Cancer? MSK Scientists Say Context Is Key

Right now, in your body, lurk thousands of cells with DNA mistakes that could cause cancer. Yet only in rare instances do these DNA mistakes, called genetic mutations, lead to a full-blown cancer. Why? The standard explanation is that it takes a certain number of genetic “hits” to a cell’s DNA to push a cell … Continued

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When cancer cells “put all their eggs in one basket”

Normal cells usually have multiple solutions for fixing problems. For example, when DNA becomes damaged, healthy white blood cells can use several different strategies to make repairs. But cancer cells may “put all their eggs in one basket,” getting rid of all backup plans and depending on just one pathway to mend their DNA. Cold … Continued

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PRESS RELEASE: THE PERSHING SQUARE SOHN CANCER RESEARCH ALLIANCE AWARDS $3.6 MILLION TO SIX EMERGING PIONEERS IN CANCER RESEARCH

THE PERSHING SQUARE SOHN CANCER RESEARCH ALLIANCE AWARDS $3.6 MILLION TO SIX EMERGING PIONEERS IN CANCER RESEARCH  The Pershing Square Sohn Prize Has Committed More Than $30 Million to 52 Scientists in the New York Area to Support Bold Cancer Research NEW YORK, MAY 18, 2021 (Business Wire) – The Pershing Square Sohn Cancer Research … Continued

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Cancer Researchers Discover What’s Driving “Brain Fog” in People With COVID-19

A unique collaboration among experts from several areas within MSK leads to findings about how inflammation appears to be driving the neurologic effects seen in some COVID-19 patients. One of the dozens of unusual symptoms that have emerged in COVID-19 patients is a condition that’s informally called “COVID brain” or “brain fog.” It’s characterized by confusion, headaches, … Continued

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PRESS RELEASE: The Pershing Square Sohn Cancer Research Alliance Is Now Accepting Applications for its 2021 Prize for Early-Career, Radically Innovative Cancer Researchers

The Pershing Square Sohn Cancer Research Alliance Is Now Accepting Applications for its 2021 Prize for Early-Career, Radically Innovative Cancer Researchers NEW YORK, OCTOBER 5, 2020 (Business Wire) – The Pershing Square Sohn Cancer Research Alliance (PSSCRA) today announced the opening of applications for its 2021 Prize for Young Investigators in Cancer Research. The prize … Continued

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PRESS RELEASE: THE PERSHING SQUARE SOHN CANCER RESEARCH ALLIANCE AWARDS $4.2M TO SEVEN RISING LEADERS IN CANCER RESEARCH

THE PERSHING SQUARE SOHN CANCER RESEARCH ALLIANCE AWARDS $4.2M TO SEVEN RISING LEADERS IN CANCER RESEARCH The Pershing Square Sohn Prize Has Supported 46 Cancer Scientists in the New York Life Science Ecosystem by Funding High-Risk, High-Reward Research NEW YORK, JULY 29, 2020 (Business Wire) – The Pershing Square Sohn Cancer Research Alliance today announced … Continued

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PRESS RELEASE: THE PERSHING SQUARE FOUNDATION AWARDS $3 MILLION TO INNOVATIVE SARS-COV-2 RESEARCH PROJECTS

THE PERSHING SQUARE FOUNDATION AWARDS $3 MILLION TO INNOVATIVE SARS-COV-2 RESEARCH PROJECTS Foundation Supports Leaders in Life Science who have Refocused Work to Combat the Coronavirus Pandemic NEW YORK, July 7, 2020 (Businesswire) – The Pershing Square Foundation (the “Foundation”) today announced that it has awarded $3 million to nineteen recipients at ten academic research institutions … Continued

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Why pancreatic ductal adenocarcinoma is so lethal

Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer, killing patients within a year. CSHL Professor Christopher Vakoc and his former postdoc Timothy Somerville discovered how pancreatic cells lose their identity, acquire a deadly new identity, and recruit nearby cells to help them grow, promote inflammation, and invade nearby tissues. This understanding could lead to new … Continued

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