An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe COVID-19 and other disorders that cause immune-mediated damage to the lungs, according to a preclinical study from researchers at Weill Cornell Medicine and Cold Spring Harbor Laboratory. The … Continued
Right now, in your body, lurk thousands of cells with DNA mistakes that could cause cancer. Yet only in rare instances do these DNA mistakes, called genetic mutations, lead to a full-blown cancer. Why? The standard explanation is that it takes a certain number of genetic “hits” to a cell’s DNA to push a cell … Continued
Messenger RNA (mRNA) vaccines may be the hottest thing in science now as they help turn the tide against COVID-19. But even before the pandemic began, Memorial Sloan Kettering researchers had already been working to use mRNA vaccine technology to treat cancer. Vinod Balachandran a physician-scientist affiliated with the David M. Rubenstein Center for Pancreatic Cancer Research and … Continued
Cancer cells can become resistant to treatments through adaptation, making them notoriously tricky to defeat and highly lethal. Cold Spring Harbor Laboratory (CSHL) Cancer Center Director and Pershing Square Sohn Cancer Research Alliance Scientific Review Council member David Tuveson and his team investigated the basis of “adaptive resistance” common to pancreatic cancer. They discovered one of the backups … Continued
Normal cells usually have multiple solutions for fixing problems. For example, when DNA becomes damaged, healthy white blood cells can use several different strategies to make repairs. But cancer cells may “put all their eggs in one basket,” getting rid of all backup plans and depending on just one pathway to mend their DNA. Cold … Continued
A unique collaboration among experts from several areas within MSK leads to findings about how inflammation appears to be driving the neurologic effects seen in some COVID-19 patients. One of the dozens of unusual symptoms that have emerged in COVID-19 patients is a condition that’s informally called “COVID brain” or “brain fog.” It’s characterized by confusion, headaches, … Continued
Tiny packets called extracellular vesicles and particles (EVPs), released by cancer and immune cells, contain specific proteins that may serve as reliable biomarkers for diagnosing early-stage cancer, according to investigators at Weill Cornell Medicine and Memorial Sloan Kettering. A new study published August 13 in Cell identifies new biomarkers in EVPs that can be used to help discriminate these … Continued
THE PERSHING SQUARE SOHN CANCER RESEARCH ALLIANCE AWARDS $4.2M TO SEVEN RISING LEADERS IN CANCER RESEARCH The Pershing Square Sohn Prize Has Supported 46 Cancer Scientists in the New York Life Science Ecosystem by Funding High-Risk, High-Reward Research NEW YORK, JULY 29, 2020 (Business Wire) – The Pershing Square Sohn Cancer Research Alliance today announced … Continued
Scientists at Cold Spring Harbor Laboratory (CSHL) have created the first mouse model of pancreatic cancer that recreates two subtypes of the human disease. The model, published July 23, 2020 in Cancer Discovery, will help researchers investigate why some pancreatic cancers are more aggressive than others and what causes them to progress, paving the way to … Continued
In a former boxing gym in Racine, firefighters are trying out a spit test that’s simpler and cheaper than PCR. Could it change how we screen for the virus? EACH MORNING AT 7, Brian Wolf, the fire chief of Racine, Wisconsin, arrives for work in a neglected corner of a building called the City Hall … Continued